The shocking NBC footage shows a local man, Marco Farrell, trying to make a last-ditch escape from the flash flooding.
The man can be heard shouting: “Oh my God, Mom!” before the mudslide sweeps dangerously down the street.
Mr Farrell can then be seen sprinting inside his house before he shouts out to close the front door, knocking over objects in the process.
Santa Barbara County Sheriff Bill Brown told Los Angeles television station KCAL: “Right now, our assets are focused on determining if anyone is still alive in any of those structures that have been damaged.”
The sheriff’s office tweeted: “Another tough day in Santa Barbara County as Search and Rescue, Fire and Law Enforcement personnel from across our county and our neighboring counties searched for survivors and evacuated people.”
The mudslides were triggered by heavy rains early on Tuesday and debris flow has destroyed 100 homes in California.
At least 500 rescuers using dogs and military helicopters have been working to try to save lives.
The crews have had to battle through waist-deep mud, fallen trees and other debris.
Celebrities, such as television personality Oprah Winfrey and talk-show host Ellen DeGeneres, who both live in the upscale hillside community of Montecito, are among those with properties affected.
DeGeneres said on her talk show the picturesque town of 9,000 is a “tight-knit” community.
“It’s not just a wealthy community, it’s filled with a lot of different types of people from all backgrounds,” she said.