Saffie Rose Roussos was at the Ariana Grande concert last night when a suicide bomber detonated an explosive device – killing at least 22 and injuring dozens.
The little girl was at the gig with her sister, Ashlee, and her mum, Lisa, along with 21,000 gig-goers.
Saffie, whose family is from the north west of England, has not been seen since the deadly attack at around 10.33pm last night.
Her mum and sister are said to be in hospital with shrapnel injuries that are not life threatening.
A friend of the family has appealed for help on Facebook in a post urging anyone with information to contact her.
Hannah Melling wrote: “My friend Lisa and her daughters Ashlee and Saffie were at the concert last night.
“Saffie-Rose, 8-years-old is still missing.
“Her mum Lisa and sister Ash are in hospital with shrapnel injuries which are not life threatening but Saffie is still missing.
“Ashlee’s in Bolton but lisa is in a different one.
“Please could you share this post and help find her… please contact me with ANY INFORMATION.”
Social media is awash with relatives of missing concert-goers desperately appealing for help in tracking down their loved ones.
Vikki Baker and her daughter Charlotte, who were at the Ariana Grande concert, leave the Park Inn, where they were given refuge
“Saffie-Rose, 8-years-old is still missing”
The appeal comes after Georgina Bethany Callander was the first victim of the attack to be named.
The teen, 18, is said to have died in hospital with her mother at her bedside this morning, a friend told the Evening Standard.
In a heartrending tweet, she wrote she was “so excited” to see the American singer and actress on Sunday night – just hours before the carnage unfolded.
Tweeting at the singer, who she was pictured with two years ago, she posted: “So excited to see you tomorrow.”
Heartfelt tributes have been pouring in social media for the teen, who has been described as a “ray of sunshine
Facebook also activated its “safety check” feature so people can let others know they were safe following the attack.
Police are urging people to call a casualty hotline – 0161 856 9400 – to check on the welfare of those missing.
The Prime Minister Theresa May confirmed it is being treated as an “appalling terrorist attack”.
Terrified fans who escaped the deadly explosion were left struggling to make it home after nearby Victoria station was evacuated and all trains and trams cancelled.
But kind-hearted strangers rallied to help, with hundreds of Manchester locals offering up places to stay for the night using the #roomformanchester hashtag.