See the England v Slovakia confirmed line-ups below…
Victory would send the Three Lions five points clear of second-placed Slovakia with two games left to play, clearing their path to Russia.
However, nerves are high following the underwhelming win in Malta on Friday night.
Three late goals made the scoreline a flattering 4-0, but Gareth Southgate’s side were unconvincing for much of the match.
So, who has Southgate selected for the Wembley clash? The confirmed teams can be seen, in full, below…
England XI: Hart, Walker, Cahill, Jones, Bertrand, Dier, Henderson, Oxlade-Chamberlain, Alli, Rashford, Kane